Targets in osteoporosis treatment.
نویسندگان
چکیده
1 Division of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhaes Hospital, Brazilian Ministry of Health, University of Pernambuco Medical School, Recife, PE, Brazil 2 Division of Endocrinology, University of São Paulo Medical School in Ribeirao Preto (FMRP/ USP), Ribeirao Preto, SP, Brazil 3 Division of Endocrinology, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil 4 Department of Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil
منابع مشابه
Bone biology, signaling pathways, and therapeutic targets for osteoporosis.
Major advances have occurred recently in the treatment of osteoporosis in recent years. Most patients are currently treated with bisphosphonates, denosumab, raloxifene, or teriparatide, and in some countries, strontium ranelate. Strontium ranelate and calcitonin have recently had their use restricted due to cardiovascular concerns and malignancy, respectively. The available agents have generall...
متن کاملIn silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach
BACKGROUND Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS The pharmacophore-based PharmaDB targets da...
متن کاملA Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis
BACKGROUND Osteoporosis is a complex bone disorder with a genetic predisposition, and is a cause of health problems worldwide. In China, Curculigo orchioides (CO) has been widely used as a herbal medicine in the prevention and treatment of osteoporosis. However, research on the mechanism of action of CO is still lacking. The aim of this study was to identify the absorbable components, potential...
متن کاملRecurrent hip fracture prevention with osteoporosis management
Abstract Background: Osteoporosis is a major public health threat, and hip fracture is a serious consequence of osteoporosis. Apatient with an osteoporosis-related hip fracture has an increased risk for a second hip fracture. The effect of osteoporosis management on the risk of recurrent hip fracture was evaluated in this study. Methods: 58 hip fracture patients older than 50yr and BMD < 2.5 w...
متن کاملSclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges
It is estimated that over 200 million adults worldwide have osteoporosis, a disease that has increasing socioeconomic impact reflected by unsustainable costs associated with disability, fracture management, hospital stays, and treatment. Existing therapeutic treatments for osteoporosis are associated with a variety of issues relating to use, clinical predictability, and health risks. Consequent...
متن کاملThe Effects of Marine Algae on Osteoporosis
Background: Osteoporosis is a prevalent bone disease caused by an imbalance between bone formation and resorption. Nutritional factors are involved in the prevention of osteoporosis. Several treatments exist for osteoporosis including bisphosphonates, parathyroid hormone, estrogen therapy, and hormone therapy, which have their own side effects. In the quest for an appropriate treatment for os...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Arquivos brasileiros de endocrinologia e metabologia
دوره 58 5 شماره
صفحات -
تاریخ انتشار 2014